Statins are well-established drugs for primary and secondary prevention of cardiovascular diseases. Many statin cholesterol-lowering independent actions, known as 'pleiotropic effects', have been identified in different cell types, including modulation of inflammation, oxidative stress, apoptosis, cell proliferation, immune response and platelet aggregation. Recent evidence suggested an additional pleiotropic effect of statins on cellular senescence mediated by their interaction with telomere maintenance system. In this special report, we will present the most important findings regarding the association between statins therapy and telomere dynamic.
The association between statins and telomere shortening
Boccardi, Virginia;
2014
Abstract
Statins are well-established drugs for primary and secondary prevention of cardiovascular diseases. Many statin cholesterol-lowering independent actions, known as 'pleiotropic effects', have been identified in different cell types, including modulation of inflammation, oxidative stress, apoptosis, cell proliferation, immune response and platelet aggregation. Recent evidence suggested an additional pleiotropic effect of statins on cellular senescence mediated by their interaction with telomere maintenance system. In this special report, we will present the most important findings regarding the association between statins therapy and telomere dynamic.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
