An influx drug/proton-antiporter of unknown structure was functionally evidenced at the blood-brain barrier (BBB). This transporter, which handles some psychoactive drugs like diphenhydramine, clonidine, oxycodone, nicotine, and cocaine, could represent a new pharmacological target in drug addiction therapy. However, drugs/inhibitors that produce effective transporter inhibition/modulation in vivo are presently unknown.
Pharmacophore-based discovery of inhibitors of a novel drug proton-antiporter in human brain endothelial hCMEC/D3 cell line
GORACCI, LAURA;CRUCIANI, Gabriele
2015
Abstract
An influx drug/proton-antiporter of unknown structure was functionally evidenced at the blood-brain barrier (BBB). This transporter, which handles some psychoactive drugs like diphenhydramine, clonidine, oxycodone, nicotine, and cocaine, could represent a new pharmacological target in drug addiction therapy. However, drugs/inhibitors that produce effective transporter inhibition/modulation in vivo are presently unknown.File in questo prodotto:
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