An increasing number of investigations shows an association between intrauterine growth retardation (IUGR) and limited fetal kidney development. Assessment of kidney growth is currently performed using ultrasounds scans; however, to date, no biochemical marker has been evaluated in association to renal volume reduction and IUGR. Twenty 20 neonates with IUGR and 34 healthy controls were prospectively recruited from the newborn nursery at S. Maria della Misericordia’s Hospital. Renal volumes were closely correlated to gestational age and to birth weight. Their measurements in IUGR newborns were significantly lower than those found in controls. Conversely, urinary Cys-C levels in IUGR were significantly higher then those found in controls.
REDUCED RENAL VOLUMES AND ELEVATED LEVELS OF CYSTATIN-C IN THE URINE OF NEONATES WITH IUGR
BARBATI, Antonella;CAPPUCCINI, BENITO;AISA, Maria Cristina;GRASSELLI, CHIARA;ZAMARRA, MARIAROSALBA;ORLACCHIO, Aldo;CLERICI, Graziano;DI RENZO, Giancarlo
2015
Abstract
An increasing number of investigations shows an association between intrauterine growth retardation (IUGR) and limited fetal kidney development. Assessment of kidney growth is currently performed using ultrasounds scans; however, to date, no biochemical marker has been evaluated in association to renal volume reduction and IUGR. Twenty 20 neonates with IUGR and 34 healthy controls were prospectively recruited from the newborn nursery at S. Maria della Misericordia’s Hospital. Renal volumes were closely correlated to gestational age and to birth weight. Their measurements in IUGR newborns were significantly lower than those found in controls. Conversely, urinary Cys-C levels in IUGR were significantly higher then those found in controls.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
