Prematurity and IUGR are associated with increased risk of developing renal postnatal injuries in the early postnatal period and in later life.Neonates at 30-40 days of corrected age without congenital abnormality or urinary tract infection were recruited and grouped into three categories: IUGR (diagnosed by a birth weight below the 10th centile); PR and healthy controls defined as appropriate for gestational age. AGA babies displayed higher levels of all surrogate markers of Nne (i.e. GA, BW, CV and RV) compared to IUGR and PR ones. This study indicates that at 30-40 days of corrected age, kidneys of PR and IUGR neonates are characterized by a tubular impairment/injury that associates to reduced Nne.
VALUATION OF BI OCHEMICAL PARAMETER S OF RENAL IMPAIRMENT/INJURY AND SURROGATE MARKER S OF NEPHRON NUMBER IN IUGR AND PRETERM NEONATES AT 30-40 DAYS OF POSTNATAL CORRECTED AGE
CAPPUCCINI, BENITO;BARBATI, Antonella;ORLACCHIO, Aldo;BAGLIONI, MAURO
2015
Abstract
Prematurity and IUGR are associated with increased risk of developing renal postnatal injuries in the early postnatal period and in later life.Neonates at 30-40 days of corrected age without congenital abnormality or urinary tract infection were recruited and grouped into three categories: IUGR (diagnosed by a birth weight below the 10th centile); PR and healthy controls defined as appropriate for gestational age. AGA babies displayed higher levels of all surrogate markers of Nne (i.e. GA, BW, CV and RV) compared to IUGR and PR ones. This study indicates that at 30-40 days of corrected age, kidneys of PR and IUGR neonates are characterized by a tubular impairment/injury that associates to reduced Nne.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
