Sleep deprivation induced by the platform technique is considered to be a heavy stressful situation in rats. At the end of the sleep deprivation period (72 h) the rat displayed particular behavior characterized by wakefulness, a high degree of motor and exploratory activity, increased alertness and reactivity to environmental stimuli. Our previous results indicated that this behavior was antagonized by the administration of the opioid receptor antagonist naloxone and increased by opioid agonists. In this paper we show that concomitantly with this behavior, a decreased B(max) of mu and delta-opioid receptors is present in the limbic system of these animals. These data suggest an active role of limbic-mu and delta-receptors in the generation of arousal and insomnia related to sleep deprivation induced stress.
Sleep deprivation as a possible animal model of mania: role of dopamine and opioids
Tortorella, Alfonso Antonio Vincenzo
1991
Abstract
Sleep deprivation induced by the platform technique is considered to be a heavy stressful situation in rats. At the end of the sleep deprivation period (72 h) the rat displayed particular behavior characterized by wakefulness, a high degree of motor and exploratory activity, increased alertness and reactivity to environmental stimuli. Our previous results indicated that this behavior was antagonized by the administration of the opioid receptor antagonist naloxone and increased by opioid agonists. In this paper we show that concomitantly with this behavior, a decreased B(max) of mu and delta-opioid receptors is present in the limbic system of these animals. These data suggest an active role of limbic-mu and delta-receptors in the generation of arousal and insomnia related to sleep deprivation induced stress.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
