Increased oxidative stress in adipose tissue (AT) emerges as an inducer of obesity-linked insulin resistance. Here we tested the hypothesis whether free-radical derived oxysterols are formed by, and accumulate in, human adipocytes. Moreover, we asked whether increased accumulation of oxysterols characterizes the adipose cells of obese patients with T2D (OBT2D) as compared with lean, nondiabetic controls (CTRL). Finally, we studied the effects of the free radical-derived oxysterols on adipogenic differentiation of adipose-derived stem cells (ASCs).
Free radical-derived oxysterols: novel adipokines modulating adipogenic differentiation of adipose precursor cells
MURDOLO, Giuseppe;PIRODDI, MARTA;BARTOLINI, DESIREE;GALLI, Francesco
2016
Abstract
Increased oxidative stress in adipose tissue (AT) emerges as an inducer of obesity-linked insulin resistance. Here we tested the hypothesis whether free-radical derived oxysterols are formed by, and accumulate in, human adipocytes. Moreover, we asked whether increased accumulation of oxysterols characterizes the adipose cells of obese patients with T2D (OBT2D) as compared with lean, nondiabetic controls (CTRL). Finally, we studied the effects of the free radical-derived oxysterols on adipogenic differentiation of adipose-derived stem cells (ASCs).File in questo prodotto:
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