We report herein a clean multistep flow process that starting from α,β-unsaturated ketones 1 allows the preparation of N-Boc-γ-amino alcohols 3 in high yields. The final products have been isolated in pure form without any additional purification step. The cleanness and environmental efficiency achieved using our protocol are proven by the calculation of green metrics such as E-factors.
An Efficient and Waste-Minimized One-Pot Procedure for the Preparation of N-Boc-γ‑amino Alcohols Starting from α,β-Unsaturated Ketones in Flow
BALLERINI, ELEONORA;PIZZO, Ferdinando;PIERMATTI, Oriana;VACCARO, Luigi
2016
Abstract
We report herein a clean multistep flow process that starting from α,β-unsaturated ketones 1 allows the preparation of N-Boc-γ-amino alcohols 3 in high yields. The final products have been isolated in pure form without any additional purification step. The cleanness and environmental efficiency achieved using our protocol are proven by the calculation of green metrics such as E-factors.File in questo prodotto:
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