Herein is reported the first decarboxylative oxidation of α-keto acids promoted by sodium metabisulfite (Na2S2O5) to obtain 2-substituted benzothiazoles and benzoselenazoles. Diaryl disulfides and diselenides were used as chalcogen sources and the desired products were obtained in moderate to excellent yields. This protocol does not require inert atmosphere, transition metals or drastic reaction conditions and CO2 is released as an environmental benign co-product. The presence of Na2S2O5 was essential to guarantee the reaction completion and maximum yield of products.
alpha-Keto Acids as Acylating Agents in the Synthesis of 2-Substituted Benzothiazoles and Benzoselenazoles
SANTI, Claudio;
2017
Abstract
Herein is reported the first decarboxylative oxidation of α-keto acids promoted by sodium metabisulfite (Na2S2O5) to obtain 2-substituted benzothiazoles and benzoselenazoles. Diaryl disulfides and diselenides were used as chalcogen sources and the desired products were obtained in moderate to excellent yields. This protocol does not require inert atmosphere, transition metals or drastic reaction conditions and CO2 is released as an environmental benign co-product. The presence of Na2S2O5 was essential to guarantee the reaction completion and maximum yield of products.File in questo prodotto:
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