An efficient and metal-free synthesis of biaryls and heterobiaryls has been developed through a key three-component reaction involving benzylideneacetones, isopropenyl acetate and methyl propiolate under high pressure (9 kbar) and mild reaction temperatures (40 °C). The described synthetic protocol provides rapid access to novel, highly functionalized and metal-uncontamined 1,1′-biaryls and heterobiaryls in an energy- and step-economic fashion.
High pressure promoted multicomponent and metal-free synthesis of polyfunctionalized biaryls
MINUTI, Lucio
;TEMPERINI, Andrea;PIAZZOLLA, FRANCESCA
2017
Abstract
An efficient and metal-free synthesis of biaryls and heterobiaryls has been developed through a key three-component reaction involving benzylideneacetones, isopropenyl acetate and methyl propiolate under high pressure (9 kbar) and mild reaction temperatures (40 °C). The described synthetic protocol provides rapid access to novel, highly functionalized and metal-uncontamined 1,1′-biaryls and heterobiaryls in an energy- and step-economic fashion.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
