An efficient and metal-free synthesis of biaryls and heterobiaryls has been developed through a key three-component reaction involving benzylideneacetones, isopropenyl acetate and methyl propiolate under high pressure (9 kbar) and mild reaction temperatures (40 °C). The described synthetic protocol provides rapid access to novel, highly functionalized and metal-uncontamined 1,1′-biaryls and heterobiaryls in an energy- and step-economic fashion.

High pressure promoted multicomponent and metal-free synthesis of polyfunctionalized biaryls

MINUTI, Lucio
;
TEMPERINI, Andrea;PIAZZOLLA, FRANCESCA
2017

Abstract

An efficient and metal-free synthesis of biaryls and heterobiaryls has been developed through a key three-component reaction involving benzylideneacetones, isopropenyl acetate and methyl propiolate under high pressure (9 kbar) and mild reaction temperatures (40 °C). The described synthetic protocol provides rapid access to novel, highly functionalized and metal-uncontamined 1,1′-biaryls and heterobiaryls in an energy- and step-economic fashion.
2017
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1416327
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