Herein we report the unprecedented Fujiwara–Moritani reaction catalysed by the commercially available heterogeneous palladium catalyst Pd/C. The reaction works efficiently in GVL, a biomass derived solvent, in the coupling between variously substituted acetanilides and electron-poor alkenes, with complete selectivity towards the ortho-substitution. Moreover, the catalyst can be easily recycled and reused for consecutive reaction runs. We also developed a continuous-flow procedure, through an easily accessible tailor-made reactor, which allows the production of C–H alkenylated products on grams per hour scale.

Heterogeneous C–H alkenylations in continuous-flow: oxidative palladium-catalysis in a biomass-derived reaction medium

FERLIN, FRANCESCO;SANTORO, STEFANO;VACCARO, Luigi
2017

Abstract

Herein we report the unprecedented Fujiwara–Moritani reaction catalysed by the commercially available heterogeneous palladium catalyst Pd/C. The reaction works efficiently in GVL, a biomass derived solvent, in the coupling between variously substituted acetanilides and electron-poor alkenes, with complete selectivity towards the ortho-substitution. Moreover, the catalyst can be easily recycled and reused for consecutive reaction runs. We also developed a continuous-flow procedure, through an easily accessible tailor-made reactor, which allows the production of C–H alkenylated products on grams per hour scale.
2017
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1419106
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