A novel approach to synthesize hydroxy lactones using flow chemistry is reported. The system could be applied to a variety of functionalized alkenoic acids allowing the simple and eco-friendly generation of lactonic products within one hour (50 min). The reaction was optimized in terms of efficiency, productivity, resources and eco-sustainability using an integrated flow process assisted by in-line work-up and purification. In one example, the method was scaled to deliver 22 mmol of the product.

Selective continuous flow synthesis of hydroxy lactones from alkenoic acids

Cerra, B.;Mangiavacchi, F.;Santi, C.;Lozza, A. M.;Gioiello, A.
2017

Abstract

A novel approach to synthesize hydroxy lactones using flow chemistry is reported. The system could be applied to a variety of functionalized alkenoic acids allowing the simple and eco-friendly generation of lactonic products within one hour (50 min). The reaction was optimized in terms of efficiency, productivity, resources and eco-sustainability using an integrated flow process assisted by in-line work-up and purification. In one example, the method was scaled to deliver 22 mmol of the product.
2017
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1421786
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