A novel approach to synthesize hydroxy lactones using flow chemistry is reported. The system could be applied to a variety of functionalized alkenoic acids allowing the simple and eco-friendly generation of lactonic products within one hour (50 min). The reaction was optimized in terms of efficiency, productivity, resources and eco-sustainability using an integrated flow process assisted by in-line work-up and purification. In one example, the method was scaled to deliver 22 mmol of the product.
Selective continuous flow synthesis of hydroxy lactones from alkenoic acids
Cerra, B.;Mangiavacchi, F.;Santi, C.;Lozza, A. M.;Gioiello, A.
2017
Abstract
A novel approach to synthesize hydroxy lactones using flow chemistry is reported. The system could be applied to a variety of functionalized alkenoic acids allowing the simple and eco-friendly generation of lactonic products within one hour (50 min). The reaction was optimized in terms of efficiency, productivity, resources and eco-sustainability using an integrated flow process assisted by in-line work-up and purification. In one example, the method was scaled to deliver 22 mmol of the product.File in questo prodotto:
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