Melanoma research in human medicine demonstrated that this tumor has great skills in evading immune system control, even by reprogramming it to immunotolerance against the tumor itself. At now, few studies have been performed on the role of immune system in canine melanocytic tumors. Aim of our study is to describe canine melanocytic tumors immune environment, focusing on the immunosuppressive molecules FoxP3 (expressed mainly on Tregs), indoleamine 2,3-dioxygenase (IDO, an immunoregulatory enzyme) and CTLA-4 (a key receptor for central and peripheral immune tolerance). IL-2 was also investigated, being implied both in survival and homeostasis of Tregs.

A closer look into immune microenvironment of canine melanocytic tumors: FoxP3, IDO and CTLA-4 expression as markers of immunosuppression

Ilaria Porcellato
Membro del Collaboration Group
;
Katia Cappelli
Membro del Collaboration Group
;
Stefano Capomaccio
Membro del Collaboration Group
;
Leonardo Leonardi
Membro del Collaboration Group
;
Luca Mechelli
Membro del Collaboration Group
;
Chiara Brachelente
Membro del Collaboration Group
2018

Abstract

Melanoma research in human medicine demonstrated that this tumor has great skills in evading immune system control, even by reprogramming it to immunotolerance against the tumor itself. At now, few studies have been performed on the role of immune system in canine melanocytic tumors. Aim of our study is to describe canine melanocytic tumors immune environment, focusing on the immunosuppressive molecules FoxP3 (expressed mainly on Tregs), indoleamine 2,3-dioxygenase (IDO, an immunoregulatory enzyme) and CTLA-4 (a key receptor for central and peripheral immune tolerance). IL-2 was also investigated, being implied both in survival and homeostasis of Tregs.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1438974
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact