Melanoma research in human medicine demonstrated that this tumor has great skills in evading immune system control, even by reprogramming it to immunotolerance against the tumor itself. At now, few studies have been performed on the role of immune system in canine melanocytic tumors. Aim of our study is to describe canine melanocytic tumors immune environment, focusing on the immunosuppressive molecules FoxP3 (expressed mainly on Tregs), indoleamine 2,3-dioxygenase (IDO, an immunoregulatory enzyme) and CTLA-4 (a key receptor for central and peripheral immune tolerance). IL-2 was also investigated, being implied both in survival and homeostasis of Tregs.
A closer look into immune microenvironment of canine melanocytic tumors: FoxP3, IDO and CTLA-4 expression as markers of immunosuppression
Ilaria Porcellato
Membro del Collaboration Group
;Katia CappelliMembro del Collaboration Group
;Stefano CapomaccioMembro del Collaboration Group
;Leonardo LeonardiMembro del Collaboration Group
;Luca MechelliMembro del Collaboration Group
;Chiara BrachelenteMembro del Collaboration Group
2018
Abstract
Melanoma research in human medicine demonstrated that this tumor has great skills in evading immune system control, even by reprogramming it to immunotolerance against the tumor itself. At now, few studies have been performed on the role of immune system in canine melanocytic tumors. Aim of our study is to describe canine melanocytic tumors immune environment, focusing on the immunosuppressive molecules FoxP3 (expressed mainly on Tregs), indoleamine 2,3-dioxygenase (IDO, an immunoregulatory enzyme) and CTLA-4 (a key receptor for central and peripheral immune tolerance). IL-2 was also investigated, being implied both in survival and homeostasis of Tregs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
