The microencapsulation of plasticizing molecules, such as 4-methoxy chalcone (4MC), can raise serious stability issues in microparticle (MP) manufacturing and storage, especially when employing low glassy pseudo-plastic polymers, such as polylactides (PLA) and polylactide-co-glycolides (PLGA). In this work, two distinct steps were undertaken: (1) the study of the effect on manufacturing and storage of 4MC loading in polyester MP and (2) the investigation of a new stabilization strategy based on 4MC intercalation into a stearate-modified hydrotalcite (sHTC).
A Novel Stabilizing Approach to Improve the Manufacturing of Biodegradable Microparticles Entrapping Plasticizing Active Molecules: the Case of 4-Methoxychalcone
Giovagnoli, Stefano
Conceptualization
;Vivani, Riccardo;Ricci, Maurizio
2019
Abstract
The microencapsulation of plasticizing molecules, such as 4-methoxy chalcone (4MC), can raise serious stability issues in microparticle (MP) manufacturing and storage, especially when employing low glassy pseudo-plastic polymers, such as polylactides (PLA) and polylactide-co-glycolides (PLGA). In this work, two distinct steps were undertaken: (1) the study of the effect on manufacturing and storage of 4MC loading in polyester MP and (2) the investigation of a new stabilization strategy based on 4MC intercalation into a stearate-modified hydrotalcite (sHTC).File in questo prodotto:
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