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Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial

Kasner, Scott E;Swaminathan, Balakumar;Lavados, Pablo;Sharma, Mukul;Muir, Keith;Veltkamp, Roland;Ameriso, Sebastian F;Endres, Matthias;Lutsep, Helmi;Messé, Steven R;Spence, J David;Nedeltechev, Krassen;Perera, Kanjana;Santo, Gustavo;Olavarria, Veronica;Lindgren, Arne;Bangdiwala, Shrikant;Shoamanesh, Ashkan;Berkowitz, Scott D;Mundl, Hardi;Connolly, Stuart J;Hart;Robert G. Abdelhamid N;Abdul Rahman D;Abdul-Saheb M;Abreu P;Abroskina M;Abu Ahmad F;Accassat S;Acciarresi M;Adami A;Ahmad N;Ahmed F;Alberto Hawkes M;Alemseged F;Ali A;Altavilla R;Alwis L;Amarenco P;Amaro S;Amaya Sanchez LE;Amelia Pinto A;Ameriso SF;Amin H;Amino T;Amjad AK;Anagnostou E;Andersen G;Anderson C;Anderson DC;Andrea Falco M;Andres Mackinnon F;Andreu D;Androulakis M;Angel Gamero M;Angel Saredo G;Angeles Diaz R;Angels Font M;Anticoli S;Arauz A;Arauz Gongora AA;Araya P;Arenillas Lara JF;Arias Rivas S;Arnold M;Augustin S;Avelar W;Azevedo E;Babikian V;Bacellar A;Badalyan K;Bae HJ;Baez Martinez EM;Bagelmann H;Bailey P;Bak Z;Baker M;Balazs A;Baldaranov D;Balogun I;Balueva T;Bankuti Z;Bar M;Baranowska A;Bardutzky J;Barker Trejo S;Barlinn J;Baronnet F;Barroso C;Barteys M;Bartolottiova T;Barulin A;Bas M;Bashir S;Basile V;Bathe-Peters R;Bathula R;Batista C;Batur Caglayan H;Baumgartner P;Bazan R;Bazhenova O;Beaudry M;Beer J;Behnam Y;Beilei C;Beinlich A;Bejot Y;Belkin A;Benavente OR;Benjamin A;Berardi V;Bereczki D;Berkowitz SD;Berlingieri J;Berrios W;Berrouschot J;Bhandari M;Bhargavah M;Bicker H;Bicsak T;Bilik M;Bindila D;Birchenall J;Birnbaum L;Black T;Blacker D;Blacquiere D;Blanc-Labarre C;Blank C;Blazejewska-Hyzorek B;Bloch S;Bodiguel E;Bogdanov E;Boos L;Borcsik L;Bornstein N;Bouly S;Braga G;Bragado I;Bravi MC;Brokalaki C;Brola W;Brouns R;Bruce D;Brzoska-Mizgalska J;Buck B;Buksinska-Lisik M;Burke J;Burn M;Bustamante G;Cabrejo L;Cai K;Cajaraville S;Calejo M;Calvet D;Campillo J;Campos Costa E;Camps P;Can Alaydin H;Candeloro E;Canepa C;Cantu Brito CG;Cappellari M;Carcel C;Cardona Portela P;Cardoso F;Carek M;Carletti M;Carlos Portilla J;Caruso P;Casado-Naranjo I;Castellini P;Castro D;Castro Meira F;Cavallini A;Cayuela Caudevilla N;Cenciarelli S;Cereda C;Cerrone P;Chakrabarti A;Chaloulos-Iakovidis P;Chamorro A;Chandrasena D;Chang DI;Che C;Chembala J;Chen J;Chen Z;Chen T;Chen H;Chen X;Chen H;Chen G;Chen J;Chen J;Chen L;Chen S;Cheripelli B;Chin M;Chiquete Anaya E;Chorazy M;Christensen H;Christensen T;Christian L;Chu F;Chung CS;Clark W;Clarke R;Claverie S;Clemente Agostoni E;Clissold B;Coelho J;Cohen D;Colakoglu S;Collas D;Condurso R;Connolly SJ;Consoli D;Constantin C;Constantino Silva AB;Contardo L;Corlobe A;Correia M;Correia C;Cortijo Garcia E;Coull B;Coutts S;Coveney S;Cras P;Crols R;Crozier S;Csanyi A;Csiba L;Csontos K;Csuha R;Cui L;Cunha L;Curtze S;Czerska M;Czlonkowska A;Czurko M;Czuryszkiewicz M;Dagnino M;Dai C;Daineko A;Dalek G;Damgaard D;Danese A;Dani K;Danku V;Dario Toledo W;Dávalos A;De Havenon A;De Keyser J;De Klippel N;De La Torre J;De Pauw A;De Smedt A;De Torres R;De Vries Basson MM;Dearborn J;Deganutto R;Degeorgia M;Deguchi I;Del Giudice A;Delcourt C;Delgado-Mederos R;Della Marca G;Delpont B;Deltour S;Demets DL;Dennis M;Desai J;Devine J;Dhollander I;Di Mascio MT;Diaconu M;Diaz Otero F;Dietzel J;Diez-Tejedor E;Ding N;Ding J;Ding J;Diomedi M;Dioszeghy P;Distefano M;Domigo V;Dorodnicov E;Dossi D;Doubal F;Druzenko I;Du P;Du J;Duman T;Duodu Y;Dutta D;Dylewicz L;Eckstein J;Ehrensperger E;Ehrlich S;Einer Allende G;Elena Halac B;Elyas S;Endres M;Engelbrecht JM;Engelter S;Epinat M;Eren F;Esbjornsson M;Escribano B;Escudero I;Esisi B;Essa B;Esterbauer M;Evans N;Eveson D;Fabio S;Fang L;Fanta S;Fares M;Fatar M;Faust K;Favate A;Fazekas F;Federica Denaro M;Fedin A;Felipe Amaya P;Feng J;Ferencova K;Fernanda Gilli M;Fernandez MD;Fernandez Pirrone PN;Fernandez Vera J;Ferrari J;Ferreira A;Ferreira Junior G;Fidler M;Field D;Field T;Figueroa C;Fiksa J;Filipov A;Firstenfeld A;Fisch L;Fischer U;Fisselier M;Fiszer U;Fluri F;Fortea G;Fotherby K;Fraczek A;France E;Freitas G;Frey S;Frick M;Friedman A;Friedrich M;Frisullo G;Fryze W;Fuentes Gimeno B;Fujigasaki H;Fukuyama K;Furlan A;Furlanis G;Furnace J;Gabriel M;Gabriel Reich E;Gagliardi RJ;Galati F;Galli Giqueauk E;Gallina A;Gallinella E;Gallo J;Gangadharan S;Gao Y;Garcia Lopez R;Garcia Pastor A;Garcia Sanchez SM;Garnauf M;Garnier P;Gasecki D;Gasic K;Gasiorek K;Gasser S;Gaugg M;Gebreyohanns M;Gebura K;Geng J;Geniz Clavijo M;Georg Haeusler K;Geran R;Geremek M;Gerocs Z;Ghia D;Giannandrea D;Giatsidis F;Gien Lopez JA;Gil Nunez A;Gimenez L;Giralt E;Glabinski A;Gladstone D;Gliem M;Gluszkiewicz M;Goddeau R;Gogoleva E;Gokce M;Goldemund D;Golikov K;Gomes Neto A;Gomez Schneider M;Gomez-Choco M;Gomis M;Gongora-Rivera JF;Gonysheva Y;Gonzalez L;Gonzalez Toledo ME;Gottschal M;Gozdzik I;Grabowski S;Graf S;Green D;Greer D;Gregorio T;Greisenegger S;Greshnova I;Griebe M;Grzesik M;Guan J;Guarda S;Gueguen A;Guidoux C;Guillermo Povedano P;Guillon B;Guiraudg V;Gunathilagan G;Guryanova N;Gusev V;Gustavo Persi G;Gutiérrez R;Guyler P;Gyuker N;Hachinski V;Hajas A;Hallevi H;Hankey G;Hankey GJ;Hanouskova L;Hao L;Haraguchi K;Haralur Sreekantaiah Y;Haratz S;Hargroves D;Harkness K;Harmel P;Harrasser M;Hart RG;Harvey M;Hasan R;Hasegawa Y;Hassan A;Hattori M;Hatzitolios A;Hauk M;Hayashi T;Hayhoe H;Hedna VS;Heine M;Held V;Hellwig S;Henkner J;Henninger N;Hermans S;Hernandez J;Herrero D;Hervieu-Begue M;Herzig R;Hicken L;Hieber M;Hill M;Hirose M;Hobeanu MC;Hobson B;Hochstetter M;Hoe Heo J;Hoffmann M;Holmstedt C;Hon P;Hong KS;Honma Y;Horev A;Horgan G;Horvath L;Horvath M;Hoyer C;Huang D;Huang H;Huber B;Huhtakangas J;Hussain M;Igarashi S;Iglesias Mohedano AM;Ignacio Tembl J;Impellizzeri M;Inanc Y;Ioli P;Irina Aniculaesei A;Ishida K;Itabashi R;Iversen H;Jagolino A;Jakab K;Jander S;Janka H;Jankovych J;Jansen J;Jasek L;Javier Alet M;Javor L;Jin X;Jing P;Joachim B;Joan Macleod M;Johnson M;Jose Martin J;Joyner C;Judit Szabo K;Jun-Oconnell A;Jura R;Kaczorowska B;Kadlcikova J;Kahles T;Kakaletsis N;Kakuk I;Kalinowska K;Kaminska K;Kaneko C;Kanellos I;Kapeller P;Kapica-Topczewska K;Karasz O;Karlinski M;Karlsson JE;Kasa K;Kashaeva E;Kasner SE;Kaste M;Kasza J;Katalin Iljicsov A;Katsurayama M;Kaur S;Kawanishi M;Kaygorodtseva S;Ke K;Kei A;Keilitz J;Kellner J;Kelly P;Kelly S;Kemlink D;Kerekgyarto M;Keskinarkaus I;Khairutdinova D;Khanna A;Khaw A;Kholopov M;Khoumri C;Kirpicheva S;Kirshner H;Kitagawa K;Kittner S;Kivioja R;Klein F;Kleindorfer D;Kleinig T;Klivenyi P;Knecht S;Kobayashi Y;Kobayashi A;Koch M;Koehler L;Koivu M;Kolianov V;Koltsov I;Kondo T;Konkov I;Kopecky S;Korompoki E;Korpela J;Kosarz-Lanczek K;Koutroubi A;Kovacs K;Kovacs T;Kovacs H;Kowalczyk K;Kowalska M;Krajickova D;Kral M;Krarup Hansen C;Kraska J;Krebs S;Krejci V;Kremer C;Kreuzpointer R;Krzyzanowska M;Kucken D;Kulakowska A;Kunzmann J;Kurenkova N;Kuris A;Kurkowska-Jastrzebska I;Kurtenkova N;Kurushina O;Kusnick G;Kustova M;Kuwashiro T;Kwan Cha J;Lago A;Lagutenko M;Lajos B;Lambeck J;Lamy C;Landolfi A;Lanfranconi S;Lang W;Lara Lezama LB;Lara Rodriguez B;Largo T;Lasek-Bal A;Latte L;Lauer V;Lavados P;Le Bouc R;Leal Cantu R;Lechner H;Lecouturier K;Leder S;Lee J;Lee BC;Leger A;Leira E;Leisse I;Leker R;Lembo G;Lenskaya L;Leyden J;Li G;Li M;Li S;Li J;Liamis G;Liang H;Liang Z;Ligot N;Lin H;Lindert R;Lindgren A;Linna M;Litwin T;Liu K;Liu X;Llull L;Lohninger B;Longoni M;Loomis C;Lopes D;Lopez Fernandez M;Lopez Garza N;Lord A;Louw S;Lovasz R;Lowenkopf T;Lu Z;Lubke-Detring SC;Luder R;Lujan S;Luo B;Lupinogina L;Luschin G;Lutsep H;Lvova A;Ly J;Grosse GM;Ma H;Ma C;Machado M;Machado C;Macher S;Machetanz J;Macian-Montoro F;Mackey E;Mackey A;Maclean G;Maestre-Moreno J;Magadan A;Magyar T;Mahagney A;Majid A;Majjhoo A;Makaritsis K;Mandzia J;Mangas Guijarro M;Mangion D;Manios E;Mann S;Manning L;Manno C;Manuel Garcia J;Maqueda V;Mar Castellanos M;Mar Freijo M;Marando C;Marcela Lepera S;Marcos Couto J;Maria Bruera G;Maria Greco L;Maria Lorenzo A;Maria Obmann S;Maria Roa A;Marini C;Marinkovic I;Mario Sumay G;Mario Torres C;Marko M;Markova S;Markus H;Marsh R;Marsili E;Marta Esnaola M;Marta Moreno J;Marti-Fabregas J;Martina Angelocola S;Martínez Sánchez P;Martinez-Majander N;Martins S;Marzelik O;Mastrocola S;Matamala G;Matoltsy A;Matosevic B;Matsumoto S;Maud A;Mauri Cabdevila G;May Z;Mayasi Y;Mayr A;Mazzoli T;Mcarthur K;Mccullough L;Medina Pech CE;Medlin F;Mehdiratta M;Mehta S;Mehta D;Mehta B;Melis M;Melnikova E;Mendez B;Mendonca T;Mengual Chirifie JJ;Menon N;Mensch A;Meseguer E;Messe S;Metcalf K;Meyer N;Michas F;Micheletti N;Mikulik R;Milionis H;Miller B;Milling T;Minelli C;Minhas J;Minns M;Mircea D;Mishra S;Mismas A;Mistri A;Mitrovic N;Miyake H;Modrau B;Moey A;Molina C;Molina J;Molis A;Moller J;Molnar S;Moniche F;Monosi C;Monzani V;Moonis M;Morais R;Morales L;Morales A;Morar-Precup D;Moreton F;Moro C;Morozova E;Morton M;Morvan T;Morvan E;Motko T;Mowla A;Mozhejko E;Muddegowda G;Mudhar O;Mueller T;Muhl C;Muir KW;Mundl H;Munoz S;Murphy C;Murphy S;Murtuzova A;Musuka T;Mutzenbach J;Myint M;Mysliwy W;Naccarato M;Naeije G;Nagakane Y;Natarajan I;Navaratnam D;Nave A;Nazliel B;Nedeltchev K;Nel J;Nell H;Nemeth R;Nemeth L;Neto O;Ng K;Ngeh J;Nicolas Chialvo L;Nieminen T;Nikkanen M;Nikl J;Nikoforova M;Nishino S;Nishiyama Y;Njovane X;Nogawa S;Nombela F;Norrving B;Nosek K;Nowak B;Nowakowska-Sledz E;Ntaios G;Numminen H;Nunez F;Obadia M;Oberndorfer S;Obrezan A;Ochiai J;Oczkowski W;O'Donnell MJ;Odyniec A;Oh K;Ohira M;Okamoto Y;Okpala M;Okubo S;Olah L;Olavarria V;Oleszek J;Onat Demirci N;Ondar V;Ongun G;Ooyama K;Orosz V;Ortiz R;Osseby G;Österlund-Tauriala E;Ovesen C;Ozcekic Demirhan S;Ozdoba-Rot J;Ozturk S;Ozyurt E;Pablo Grecco M;Pablo Povedano G;Paciaroni M;Padiglioni C;Pagola J;Palasik W;Panczel G;Panos L;Papadopoulos G;Papadopoulou E;Papagiannis A;Papavasileiou V;Papina M;Pardo De Donlebun JR;Parisi V;Park JM;Pasten J;Patel N;Pavlik O;Pawelczyk M;Peacock WF;Pei H;Peisker T;Pena Sedna LF;Penn A;Pentek S;Pepper E;Pereira L;Perera K;Perez Y;Perez S;Perez Leguizamon P;Pernicka M;Perry R;Persico A;Pesant Y;Peska S;Peters D;Peters G;Pettigrew L;Phan T;Philippi S;Phinney T;Pico F;Pidal A;Piechowski-Jozwiak B;Pieroni A;Pineiro S;Piras V;Pizova N;Polanco J;Polin M;Polyakov A;Polychronopoulou E;Polymeris A;Popov D;Poppe A;Postorino P;Pozzerese C;Pradhan M;Prats L;Prazdnichkova E;Prendl B;Pretorius M;Profice P;Prokopenko S;Pudov E;Pujol Lereis V;Punzo Bravo G;Purroy F;Qiu J;Qu X;Quenardelle V;Quesada Garcia H;Radrizzani L;Radtke A;Raffelsberger T;Ramirez Moreno JM;Ramos-Estebanez C;Rani A;Rapantova P;Rashed K;Rasheed Nihara A;Rasmussen J;Redondo Robles L;Reif M;Reiner P;Rekova P;Renu A;Repetto M;Reyes P;Reyes Morales S;Rha JH;Ribeiro J;Ricci S;Richard C;Rigual R;Rinaldi C;Riveira Rodriguez C;Rizzato B;Robinson TG;Rocco A;Rodrigues M;Rodriguez G;Rodriguez Campello A;Rodriguez Lucci F;Rodriguez Yanez M;Roesler C;Roffe C;Roine R;Roine S;Roldan A;Romana Pezzella F;Romano M;Roos JS;Rosso C;Rostrup Kruuse C;Roth Y;Roukens R;Roveri L;Rozanski D;Rozniecki J;Rozsa C;Rudilosso S;Ruiz Ares G;Ruiz Franco A;Rum G;Ruuskanen J;Rybinnik I;Ryota K;Saarinen J;Saavedra V;Sabben C;Sabet A;Sagris D;Sahlas J;Sakai N;Salamanca P;Salgado P;Salig S;Salletmayr T;Salnikov M;Samoshkina O;Samson Y;Sanak D;Sànchez Cerón M;Santalucia P;Santamaria Cadavid M;Santiago P;Santo G;Sanz Cuesta B;Sargento J;Sarraj A;Sas K;Sas A;Satoshi O;Satsoglou S;Sattar N;Savitz S;Savopoulos C;Saw J;Sawicka M;Sawyer R;Scandura T;Schillinger N;Schindler J;Schlachetzki F;Schneider I;Schuppner R;Schurig J;Schwarzbach CJ;Sebejova M;Seidel G;Sekaran L;Selcuk D;Selvarajah J;Semerano A;Semjen J;Semushina D;Sen S;Seok Park M;Serena J;Serhat Tokgoz O;Serles W;Serrano F;Sevin M;Seynaeve L;Shah S;Shamalov N;Shang T;Sharma M;Sharrief A;Shazam Hussain M;Shchukin I;Shen W;Shepeleva E;Shinsuke I;Shmonin A;Shoamanesh A;Shuaib A;Shulga A;Sibolt G;Sibon I;Sicilia I;Siebert M;Sieczkowska E;Sila C;Silva AA;Silva D;Silva P;Silva Y;Silvestrini M;Simony Z;Simpkins A;Singh B;Sinha D;Sipos I;Skoda O;Skowron P;Skowronska M;Sliwinska B;Slonkova J;Smolkin A;Smyth A;Sobolewski P;Sobota A;Sohn SI;Soldatov M;Solganov I;Soloveva L;Solovyeva E;Sonntag N;Soors P;Sorgun M;Soriano C;Spence D;Spengos K;Sposato L;Staaf G;Stadler K;Stakhovskaya L;Stamatelopoulos K;Steinert S;Stetkarova I;Stiehm M;Stocker R;Stoinski J;Stoll A;Stotts G;Stumpp A;Sucapane P;Suenaga T;Sun X;Sundararajan S;Sung Kim J;Suzuki H;Svaneborg N;Szasz G;Szczuchniak W;Szczyrba S;Szegedi N;Szekely A;Szewczyk Z;Szilagyi G;Szlufik S;Szoboszlai K;Szpisjak L;Sztajzel R;Sztriha L;Ta Wil SE;Taggeselle J;Takamatsu K;Takao M;Taki W;Takizawa S;Talahma M;Tamayo A;Tan J;Tanne D;Tapanainen A;Tapiola T;Tarasiuk J;Tatlisumak T;Tayal A;Tcvetkova S;Teal P;Tejada Garcia J;Tejada Meza H;Tenora D;Terceno M;Terentiou A;Tezcan S;Thaler D;Thomson A;Thouvenot E;Tiainen M;Timberg I;Timsit S;Tinchon A;Tirschwell D;Togay Isikay C;Tokunaga K;Tolino M;Toloza C;Tomelleri G;Tomoyuki K;Tomppo LM;Tong Z;Tong L;Toni D;Torres J;Tossavainen C;Toth G;Tountopoulou A;Touze E;Tovar M;Toyoda K;Trillo S;Trommer A;Tropepi D;Tryambake D;Tu H;Tuetuencue S;Tumova R;Tumpula O;Turc G;Tutaj A;Tynkkynen J;Uchiyama S;Uchwat U;Uhrinyakova L;Ulku Acar R;Uluduz Ugurlu D;Urra X;Urui S;Usero Ruiz M;Vaclavik D;Vahedi K;Valikovics A;Valpas J;Van Acker P;Van Daele W;Vanderschueren G;Vanina Jure L;Varela R;Varga Z;Varvat J;Varvyanskaya N;Vasco Salgado A;Vasko P;Vass L;Vassilopoulou S;Vastagh I;Vazquez P;Vecsei L;Veltkamp R;Venti M;Verdugo M;Verocai V;Veronica Marroquin M;Veronica Simonsini C;Veverka T;Vigl M;Vila A;Vilar C;Villanueva Osorio JA;Virta J;Vitkova E;Voglsperger B;Volna J;Von Weitzel-Mudersbach PA;Vora N;Voznyuk I;Wach-Klink A;Wacongne A;Walters D;Wang Y;Wang J;Wang L;Wang X;Wang W;Wang Y;Wang N;Wang D;Wang H;Wang X;Wang Y;Wang Y;Warnack W;Wartenberg K;Waters R;Waters M;Webb T;Weber J;Weiss G;Weissenborn K;Weitz JI;Weller B;Wen G;Weng G;Werner P;Werring D;Wester P;Whiteley W;Whiting R;Wijeratne T;Willems C;Wilson L;Wilson C;Winder T;Windt J;Winkler A;Winska-Tereszkiewicz A;Wisniewska A;Wittayer M;Wlodek A;Wojnarowska-Arendt A;Wolf M;Wolff V;Wolter C;Wong A;Wook Nah H;Worthmann H;Wu W;Wu S;Wunderlich S;Wurzinger H;Wyse DG;Xiao B;Xiaopeng W;Ximenez-Carrillo A;Xiong L;Xiong Y;Xiong W;Xu Y;Xu J;Xu Z;Yalo B;Yamada T;Yamasaki M;Yang L;Yang Y;Yang X;Yang Q;Yang B;Yang Y;Yang J;Yasuhiro I;Yee Lam M;Yegappan C;Yip S;Ylikallio E;Ylikotila P;Yongwon Jin A;Yoon BW;Yoshida Y;Yperzeele L;Yuan H;Yuasa H;Zalewska J;Zanferrari C;Zapata E;Zboznovits D;Zelenka I;Zhang C;Zhang B;Zhang S;Zhang M;Zhang X;Zhang J;Zhao L;Zhirnova O;Zhou L;Zielinska-Turek J;Zinchenko I;Ziomek M;Zitzmann A;Zweifler R;Zwiernik J.

2018