Background: Papillary tumor of the pineal region (PTPR) is a recently defined tumor entity. Its clinical course is characterized by frequent local recurrence, and patients may experience the burden of symp toms due to the anatomical location of the grow ing mass. Guidelines for treatment protocols, and the role of radiother apy are still be ing investigated. Case: We report the case of a 27year old woman who was referred to our department after she was dia gnosed with PTPR and had undergone multiple surgical interventions. We delivered adjuvant conformal radiother apy on the gross residual tumor to a total dose of 59.4 Gy (33 × 1.8 Gy). Discussion: After a followup period of 41 months, we obtained a complete response to the treatment, accord ing to the Response evaluation criteria in solid tumors criteria (RECIST). Radiation treatment was well tolerated, and the patient did not develop acute and late side effects. The neurological symp toms, which were documented at the dia gnosis and after the surgical procedure, have not been recorded at last followup. Conclusions: Formal consensus for manag ing patients with a dia gnosis of PTPR are nonexistent. Despite surgery, this tumor has a tendency to recur. Radiother apy could have a role in the adjuvant sett ing and needs to be investigated in a multicenter sett ing with a long followup.
The role of adjuvant radiother apy in the treatment of papillary tumors of the pineal region: Some general considerations and a case report
Ingrosso, G.;
2017
Abstract
Background: Papillary tumor of the pineal region (PTPR) is a recently defined tumor entity. Its clinical course is characterized by frequent local recurrence, and patients may experience the burden of symp toms due to the anatomical location of the grow ing mass. Guidelines for treatment protocols, and the role of radiother apy are still be ing investigated. Case: We report the case of a 27year old woman who was referred to our department after she was dia gnosed with PTPR and had undergone multiple surgical interventions. We delivered adjuvant conformal radiother apy on the gross residual tumor to a total dose of 59.4 Gy (33 × 1.8 Gy). Discussion: After a followup period of 41 months, we obtained a complete response to the treatment, accord ing to the Response evaluation criteria in solid tumors criteria (RECIST). Radiation treatment was well tolerated, and the patient did not develop acute and late side effects. The neurological symp toms, which were documented at the dia gnosis and after the surgical procedure, have not been recorded at last followup. Conclusions: Formal consensus for manag ing patients with a dia gnosis of PTPR are nonexistent. Despite surgery, this tumor has a tendency to recur. Radiother apy could have a role in the adjuvant sett ing and needs to be investigated in a multicenter sett ing with a long followup.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
