We report a procedure for the continuous-flow production of cyclohexanone from phenol on the basis of the use of sodium formate as a biomass-derived source of hydrogen and Pd/C as an easily accessible catalyst system. The reaction worked in water at pH 12.0 at 90 °C. By setting a packed reactor charged with the Pd/C catalyst (10 wt %) at a flow rate of 0.5 mL min−1, we achieved continuous-flow production of cyclohexanone in high yield with high selectivity and productivity.

Continuous-Flow Palladium-Catalyzed Synthesis of Cyclohexanones from Phenols using Sodium Formate as a Safe Hydrogen Source

Valentini, F;Lanari, D.;Vaccaro, L.
2018

Abstract

We report a procedure for the continuous-flow production of cyclohexanone from phenol on the basis of the use of sodium formate as a biomass-derived source of hydrogen and Pd/C as an easily accessible catalyst system. The reaction worked in water at pH 12.0 at 90 °C. By setting a packed reactor charged with the Pd/C catalyst (10 wt %) at a flow rate of 0.5 mL min−1, we achieved continuous-flow production of cyclohexanone in high yield with high selectivity and productivity.
2018
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1447114
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