We report a procedure for the continuous-flow production of cyclohexanone from phenol on the basis of the use of sodium formate as a biomass-derived source of hydrogen and Pd/C as an easily accessible catalyst system. The reaction worked in water at pH 12.0 at 90 °C. By setting a packed reactor charged with the Pd/C catalyst (10 wt %) at a flow rate of 0.5 mL min−1, we achieved continuous-flow production of cyclohexanone in high yield with high selectivity and productivity.
Continuous-Flow Palladium-Catalyzed Synthesis of Cyclohexanones from Phenols using Sodium Formate as a Safe Hydrogen Source
Valentini, F;Lanari, D.;Vaccaro, L.
2018
Abstract
We report a procedure for the continuous-flow production of cyclohexanone from phenol on the basis of the use of sodium formate as a biomass-derived source of hydrogen and Pd/C as an easily accessible catalyst system. The reaction worked in water at pH 12.0 at 90 °C. By setting a packed reactor charged with the Pd/C catalyst (10 wt %) at a flow rate of 0.5 mL min−1, we achieved continuous-flow production of cyclohexanone in high yield with high selectivity and productivity.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
