A 4-month-old dog died after showing intracranial signs a few days after a suspected viral enteritis. Grossly, the right cerebral hemisphere had a large irregular cavity external to the internal capsule. Histopathological examination revealed a cystic lesion on the right hemisphere and non-suppurative inflammation of the diencephalon and periacqueductal nervous tissue. Porencephaly associated with periventricular non-suppurative encephalitis was diagnosed. A nested PCR identified the presence of parvovirus DNA in the brain and real-time PCR typed the detected virus as canine parvovirus (CPV) type 2a. Immunohistochemistry revealed a marked cytoplasmic CPV-immunoreaction of scattered cells in the subependymal layers and choroid plexus epithelium. The porencephaly was not associated with inflammatory lesions or CPV antigen and was considered to have preceded the neurological signs. In contrast, the detection of CPV antigen in the subependymal layers and choroid plexus epithelium supported the association of this virus with the periventricular encephalitis.
Porencephaly and periventricular encephalitis in a 4-month-old puppy: detection of canine parvovirus type 2 and potential role in brain lesions
Maria Luisa Marenzoni;Greta Foiani;Maria Teresa Mandara
2019
Abstract
A 4-month-old dog died after showing intracranial signs a few days after a suspected viral enteritis. Grossly, the right cerebral hemisphere had a large irregular cavity external to the internal capsule. Histopathological examination revealed a cystic lesion on the right hemisphere and non-suppurative inflammation of the diencephalon and periacqueductal nervous tissue. Porencephaly associated with periventricular non-suppurative encephalitis was diagnosed. A nested PCR identified the presence of parvovirus DNA in the brain and real-time PCR typed the detected virus as canine parvovirus (CPV) type 2a. Immunohistochemistry revealed a marked cytoplasmic CPV-immunoreaction of scattered cells in the subependymal layers and choroid plexus epithelium. The porencephaly was not associated with inflammatory lesions or CPV antigen and was considered to have preceded the neurological signs. In contrast, the detection of CPV antigen in the subependymal layers and choroid plexus epithelium supported the association of this virus with the periventricular encephalitis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
