A new series of indole carboxamides have been synthesized through a coupling reaction. Several substitutions on the aromatic ring and on the amino acids are well tolerated, and the corresponding indole carboxamides have been obtained with good yields. The same procedure can be also extended to the pyrrole nucleus. Four of these compounds have also been screened for their antimicrobial activity against ten different yeast strains and two of them showed an antifungal activity. Further explorations are required to clarify a potential applicability in biological fields.
Synthesis and biological evaluation of new indole and pyrrole carboxamides based on amino acids
Martina Palomba;Luca Roscini;Luana Bagnoli
2019
Abstract
A new series of indole carboxamides have been synthesized through a coupling reaction. Several substitutions on the aromatic ring and on the amino acids are well tolerated, and the corresponding indole carboxamides have been obtained with good yields. The same procedure can be also extended to the pyrrole nucleus. Four of these compounds have also been screened for their antimicrobial activity against ten different yeast strains and two of them showed an antifungal activity. Further explorations are required to clarify a potential applicability in biological fields.File in questo prodotto:
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