Heterogeneous manganese-catalyzed C−H oxidative couplings were accomplished to gain access to pharmaceutically relevant 2-aminophenoxazin-3-ones and to diaminophenazine and purpurogallin moieties in excellent yields. The user-friendly K-OMS-2 oxidase strategy proved to be more versatile and robust than enzymatic catalysts-based procedures allowing a wider substrate scope and being effectively reusable as proven by leaching measurements and XRD analyses.
Heterogeneous Manganese-Catalyzed Oxidase C−H/C−O Cyclization to Access Pharmaceutically Active Compounds
Ferlin F.;Marini A.;Ascani N.;Ackermann L.;Lanari D.
;Vaccaro L.
2020
Abstract
Heterogeneous manganese-catalyzed C−H oxidative couplings were accomplished to gain access to pharmaceutically relevant 2-aminophenoxazin-3-ones and to diaminophenazine and purpurogallin moieties in excellent yields. The user-friendly K-OMS-2 oxidase strategy proved to be more versatile and robust than enzymatic catalysts-based procedures allowing a wider substrate scope and being effectively reusable as proven by leaching measurements and XRD analyses.File in questo prodotto:
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