A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit: A position paper from the Italian Group of Haematopathology (G.I.E.)

Di Napoli, A.; Remotti, D.; Agostinelli, C.; Ambrosio, M. R.; Ascani, S.; Carbone, A.; Facchetti, F.; Lazzi, S.; Leoncini, L.; Lucioni, M.; Novero, D.; Pileri, S.; Ponzoni, M.; Sabattini, E.; Tripodo, C.; Zamo, A.; Paulli, M.; Ruco, L.

doi:10.1007/s00428-019-02637-2

An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient.

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Titolo:	A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit: A position paper from the Italian Group of Haematopathology (G.I.E.)
Autori:	Di Napoli A. Remotti D. Agostinelli C. Ambrosio M. R. ASCANI, Stefano Carbone A. FACCHETTI, ANTONIO FRANCESCO Lazzi S. Leoncini L. LUCIONI, MARIELLA Novero D. Pileri S. Ponzoni M. Sabattini E. Tripodo C. ZAMOSHANSKAY, ANASTASIA Paulli M. Ruco L. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2019
Rivista:	VIRCHOWS ARCHIV
Abstract:	An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is c...rucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient.
Handle:	http://hdl.handle.net/11391/1459995
Appare nelle tipologie:	1.1 Articolo in rivista

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