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EnglishThe potential of integrating flow synthesizers, statistical design of experiments and automation has been exemplified to realize the streamlined etherification of pregnenolone to the neurosteroid 3 beta-methoxypregnenolone (MAP4343). The use of Proton Sponge (TM), online reaction monitoring, work-up, product purification, and reagent recovery are additional key features of the present study. The optimized single-step process was validated by conducting a multistep sequence that has enabled the continuous flow synthesis of MAP4343 on a laboratory scale with an overall yield of 64% via six steps from the readily available plant-derived diosgenin.
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| Titolo: | A streamlined synthesis of the neurosteroid 3β-methoxypregnenolone assisted by a statistical experimental design and automation |
| Autori: | |
| Data di pubblicazione: | 2020 |
| Rivista: | |
| Abstract: | The potential of integrating flow synthesizers, statistical design of experiments and automation has been exemplified to realize the streamlined etherification of pregnenolone to the neurosteroid 3 beta-methoxypregnenolone (MAP4343). The use of Proton Sponge (TM), online reaction monitoring, work-up, product purification, and reagent recovery are additional key features of the present study. The optimized single-step process was validated by conducting a multistep sequence that has enabled the continuous flow synthesis of MAP4343 on a laboratory scale with an overall yield of 64% via six steps from the readily available plant-derived diosgenin. |
| Handle: | http://hdl.handle.net/11391/1461891 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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