Association Between Glandular Infiltrate and Leukopenia in Sjögren Syndrome (SS): Data From the Italian Research Group on SS (GRISS)

We read with great interest the paper by Sharma, et al1, who analyzed a cohort of patients with primary Sjögren syndrome (pSS), evaluating differences between a subgroup of subjects with positive minor salivary gland (MSG) biopsy compared to patients with a negative MSG biopsy. The authors found a higher prevalence of anti-La positivity and increased levels of IgG in the former group and identified a significant upregulation of type I interferon (IFN)-regulated genes in a sample group of patients with positive MSG biopsy.