Co-evolution of the microbial communities with the mammalian host has resulted in intertwined metabolic pathways ultimately affecting physiological and pathological processes. Tryptophan derivatives of host and microbial origin are emblematic of this metabolic promiscuity. One such metabolite, indole-3-aldehyde (3-IAld), is produced by the gut microbiota and was originally identified for its ability to promote epithelial barrier functions by working as an agonist of the Aryl hydrocarbon Receptor. This original observation has been extended in the recent years to include a plethora of activities in several pathological conditions. In this review, we describe the multifaceted role of 3-IAld in host physiology, pathology and immunity and discuss how its proper clinical development may turn into a valuable therapeutic strategy.

Regulation of host physiology and immunity by microbial indole-3-aldehyde

Zelante, Teresa;Puccetti, Matteo;Giovagnoli, Stefano;Romani, Luigina
2021

Abstract

Co-evolution of the microbial communities with the mammalian host has resulted in intertwined metabolic pathways ultimately affecting physiological and pathological processes. Tryptophan derivatives of host and microbial origin are emblematic of this metabolic promiscuity. One such metabolite, indole-3-aldehyde (3-IAld), is produced by the gut microbiota and was originally identified for its ability to promote epithelial barrier functions by working as an agonist of the Aryl hydrocarbon Receptor. This original observation has been extended in the recent years to include a plethora of activities in several pathological conditions. In this review, we describe the multifaceted role of 3-IAld in host physiology, pathology and immunity and discuss how its proper clinical development may turn into a valuable therapeutic strategy.
2021
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1481359
Citazioni
  • ???jsp.display-item.citation.pmc??? 19
  • Scopus 38
  • ???jsp.display-item.citation.isi??? 38
social impact