Cerebrospinal fluid α-synuclein (CSF α-syn) represents a possible biomarker in Parkinson's disease (PD) diagnosis. CSF blood contamination can introduce a bias in α-syn measurement. To date, CSF samples with a red blood cells (RBC) count >50 RBC × 106/L or haemoglobin (Hb) concentration >200 μg/L are excluded from biomarker studies. However, investigations for defining reliable cut-off values are missing.
Cerebrospinal fluid hemoglobin levels as markers of blood contamination: relevance for α-synuclein measurement
Paciotti, SilviaInvestigation
;Bellomo, GiovanniFormal Analysis
;Eusebi, PaoloFormal Analysis
;Chiasserini, Davide
Conceptualization
;Parnetti, Lucilla
Conceptualization
2021
Abstract
Cerebrospinal fluid α-synuclein (CSF α-syn) represents a possible biomarker in Parkinson's disease (PD) diagnosis. CSF blood contamination can introduce a bias in α-syn measurement. To date, CSF samples with a red blood cells (RBC) count >50 RBC × 106/L or haemoglobin (Hb) concentration >200 μg/L are excluded from biomarker studies. However, investigations for defining reliable cut-off values are missing.File in questo prodotto:
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