A new synthesis of carboxyterfenadine (4), based on the conversion of a alpha-halo-alkylarylketone into the corresponding substituted 2-arylalkanoic ester, is described. The enantioselective synthesis of its two bioisosteric tetrazole analogs together with preliminary biological results are reported.

A new synthesis of carboxyterfenadine (fexofenadine) and its bioisoteric tetrazole analogs

NATALINI, Benedetto;PELLICCIARI, Roberto;
1999-01-01

Abstract

A new synthesis of carboxyterfenadine (4), based on the conversion of a alpha-halo-alkylarylketone into the corresponding substituted 2-arylalkanoic ester, is described. The enantioselective synthesis of its two bioisosteric tetrazole analogs together with preliminary biological results are reported.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/149679
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