Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminster-fullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report me provide the first demonstration that a water-soluble fullerene derivative, C-3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in Epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments.

C3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation induced anoikia by influencing cell adhesion ability

NATALINI, Benedetto;PELLICCIARI, Roberto;
1999

Abstract

Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminster-fullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report me provide the first demonstration that a water-soluble fullerene derivative, C-3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in Epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments.
1999
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/149755
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