Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminster-fullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report me provide the first demonstration that a water-soluble fullerene derivative, C-3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in Epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments.
C3-Fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation induced anoikia by influencing cell adhesion ability
NATALINI, Benedetto;PELLICCIARI, Roberto;
1999
Abstract
Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminster-fullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report me provide the first demonstration that a water-soluble fullerene derivative, C-3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in Epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
