Four phenolic analogues isolated from Balanophora laxiflora; methyl gallate (1, MG), 4-hydroxy-3-methoxycinnamaldehyde (2), 3-methoxycinnamic acid (3), and methyl caffeate (4, MC) were shown to have antiproliferative activity on acute myeloid leukemia (OCI-AML3) cells due to impaired cell cycle progression. Three of these compounds (1, 3, and 4) caused increased apoptosis and decreased proliferationin cells. Interestingly, MC (compound 4) significantly decreased the percentage of cells in S phase and G2/M phase, and significantly increased apoptosis in cells at low concentrations. Treatment with these compounds increased Fas ligand production and caspase-8/3, but not caspase-9-dependent, apoptosis. These results suggest that dosing with these compounds decreases proliferation and increases apoptosis in cell lines derived from hematological cancers.
Phenolic Acid Analogues from Balanophora laxiflora Inhibit Proliferation of In Vitro Acute Myeloid Leukemia Cells
Adorisio S.;Delfino D. V.
2022
Abstract
Four phenolic analogues isolated from Balanophora laxiflora; methyl gallate (1, MG), 4-hydroxy-3-methoxycinnamaldehyde (2), 3-methoxycinnamic acid (3), and methyl caffeate (4, MC) were shown to have antiproliferative activity on acute myeloid leukemia (OCI-AML3) cells due to impaired cell cycle progression. Three of these compounds (1, 3, and 4) caused increased apoptosis and decreased proliferationin cells. Interestingly, MC (compound 4) significantly decreased the percentage of cells in S phase and G2/M phase, and significantly increased apoptosis in cells at low concentrations. Treatment with these compounds increased Fas ligand production and caspase-8/3, but not caspase-9-dependent, apoptosis. These results suggest that dosing with these compounds decreases proliferation and increases apoptosis in cell lines derived from hematological cancers.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
