A novel methodology for the heterogeneous palladium-catalyzed C–H alkenylation of N-methoxybenzamides and anilides is presented. This approach is based on the use of commercially available Pd/C as catalyst and molecular oxygen as terminal oxidant, in combination with a substoichiometric amount of benzoquinone. Furthermore, the reaction can be conducted in non-toxic biomass-derived γ-valerolactone (GVL) as reaction medium. The catalytic system exploited high activity leading to good isolated yields to several interesting products. In addition, the catalyst showed a remarkable stability in the reaction conditions, allowing its recycling in consecutive reaction runs.

Pd/C-catalyzed aerobic oxidative C–H alkenylation of arenes in γ-valerolactone (GVL)

Anastasiou I.;Ferlin F.;Santoro S.;Vaccaro L.
2021

Abstract

A novel methodology for the heterogeneous palladium-catalyzed C–H alkenylation of N-methoxybenzamides and anilides is presented. This approach is based on the use of commercially available Pd/C as catalyst and molecular oxygen as terminal oxidant, in combination with a substoichiometric amount of benzoquinone. Furthermore, the reaction can be conducted in non-toxic biomass-derived γ-valerolactone (GVL) as reaction medium. The catalytic system exploited high activity leading to good isolated yields to several interesting products. In addition, the catalyst showed a remarkable stability in the reaction conditions, allowing its recycling in consecutive reaction runs.
2021
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1504467
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? ND
social impact