A novel methodology for the heterogeneous palladium-catalyzed C–H alkenylation of N-methoxybenzamides and anilides is presented. This approach is based on the use of commercially available Pd/C as catalyst and molecular oxygen as terminal oxidant, in combination with a substoichiometric amount of benzoquinone. Furthermore, the reaction can be conducted in non-toxic biomass-derived γ-valerolactone (GVL) as reaction medium. The catalytic system exploited high activity leading to good isolated yields to several interesting products. In addition, the catalyst showed a remarkable stability in the reaction conditions, allowing its recycling in consecutive reaction runs.
Pd/C-catalyzed aerobic oxidative C–H alkenylation of arenes in γ-valerolactone (GVL)
Anastasiou I.;Ferlin F.;Santoro S.;Vaccaro L.
2021
Abstract
A novel methodology for the heterogeneous palladium-catalyzed C–H alkenylation of N-methoxybenzamides and anilides is presented. This approach is based on the use of commercially available Pd/C as catalyst and molecular oxygen as terminal oxidant, in combination with a substoichiometric amount of benzoquinone. Furthermore, the reaction can be conducted in non-toxic biomass-derived γ-valerolactone (GVL) as reaction medium. The catalytic system exploited high activity leading to good isolated yields to several interesting products. In addition, the catalyst showed a remarkable stability in the reaction conditions, allowing its recycling in consecutive reaction runs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
