OBJECTIVE: To determine the effects of capillary rarefaction on cardiovascular reactivity and microcirculatory functioning in essential hypertension. DESIGN: Hypertension is associated with abnormal cardiovascular reactivity and increased vasoconstriction. Capillary rarefaction amplifies these abnormalities, which modify microcirculatory hemodynamics. Hence this study of the hemorheological pattern and the veno-arteriolar reflex in hypertensive patients and normotensive control subjects. METHODS: Sixty-one men with never-treated essential hypertension and capillary rarefaction (< 80 capillaries per field) and 20 age-matched and sex-matched controls underwent a strenuous cycle ergometer test to monitor, during exercise and recovery, the blood pressure profile and the hemorheological pattern: blood viscosity at low shear, hematocrit and leukocyte counts, soluble P-selectin levels, and red and white blood cell filterability rates. The veno-arteriolar reflex was determined by laser-Doppler flowmetry before exercise and at recovery.RESULTS Hypertensive men with < or = 72 capillaries per field had an abnormal hemorheological profile before exercise. The physiological response to exercise was observed only in the controls and in hypertensives with > or = 73 capillaries per field. Abnormal responses to exercise worsened as capillaries were more rarefied. At recovery, hemorheological parameters in hypertensives with 65-72 capillaries per field returned to baseline, remaining significantly (P < 0.05) different to control values. Variations in the hemorheological pattern in hypertensives with < 64 capillary per field persisted at recovery. The veno-arteriolar reflex followed the same pattern. CONCLUSION: A reduced microvascular network may contribute to abnormal cardiovascular reactivity and to exercise-induced rheological abnormalities in hypertension.

Capillary rarefaction and abnormal cardiovascular reactivity in hypertension

CIUFFETTI, Giovanni;SCHILLACI, Giuseppe;LOMBARDINI, Rita;PASQUALINI, Leonella;MANNARINO, Elmo
2003-01-01

Abstract

OBJECTIVE: To determine the effects of capillary rarefaction on cardiovascular reactivity and microcirculatory functioning in essential hypertension. DESIGN: Hypertension is associated with abnormal cardiovascular reactivity and increased vasoconstriction. Capillary rarefaction amplifies these abnormalities, which modify microcirculatory hemodynamics. Hence this study of the hemorheological pattern and the veno-arteriolar reflex in hypertensive patients and normotensive control subjects. METHODS: Sixty-one men with never-treated essential hypertension and capillary rarefaction (< 80 capillaries per field) and 20 age-matched and sex-matched controls underwent a strenuous cycle ergometer test to monitor, during exercise and recovery, the blood pressure profile and the hemorheological pattern: blood viscosity at low shear, hematocrit and leukocyte counts, soluble P-selectin levels, and red and white blood cell filterability rates. The veno-arteriolar reflex was determined by laser-Doppler flowmetry before exercise and at recovery.RESULTS Hypertensive men with < or = 72 capillaries per field had an abnormal hemorheological profile before exercise. The physiological response to exercise was observed only in the controls and in hypertensives with > or = 73 capillaries per field. Abnormal responses to exercise worsened as capillaries were more rarefied. At recovery, hemorheological parameters in hypertensives with 65-72 capillaries per field returned to baseline, remaining significantly (P < 0.05) different to control values. Variations in the hemorheological pattern in hypertensives with < 64 capillary per field persisted at recovery. The veno-arteriolar reflex followed the same pattern. CONCLUSION: A reduced microvascular network may contribute to abnormal cardiovascular reactivity and to exercise-induced rheological abnormalities in hypertension.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/151311
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