We give a comment on the article by le Roux (le Roux CW, Aylwin SJ, Batterham RL, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg. 2006;243:108–114). In this article the authors investigated the effect of bariatric surgery on gut hormones secretion. To investigate the hormonal changes after Roux-en-Y gastric bypass (RYGB), basal and meal-stimulated secretion of peptide YY, glucagon-like peptide-1 (GLP-1), polypeptide, insulin, leptin and ghrelin were compared with a group of patients undergoing gastric banding and with 2 control groups composed, respectively, by lean and obese subjects. To further investigate the role of the hormonal response observed in humans, a jejuno-intestinal bypass (JIB) was carried out in Wistar rats. The main goal in the animal experiment was to reproduce hormonal changes observed in humans, postulating that these changes are due to the early arrival of nutrients in the terminal ileum as consequence of the bypass of the jejunum, and to demonstrate the role of PYY in reduction of appetite after bariatric procedures entailing with bypass of part of the small bowel. Comparing JIB rats with sham-operated animals, JIB rats experienced a significant postoperative weight loss with a parallel reduction in food intake. Moreover, the authors excluded the presence of malabsorption in the JIB group using a ballistic bomb calorimeter, therefore referring the modifications in body weight and in food intake solely to the hormonal variations. We discuss some technical aspects of the experimental protocol.
Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
PATRITI, Alberto;AISA, Maria Cristina;FACCHIANO, ENRICO;GULLA', Nino
2007
Abstract
We give a comment on the article by le Roux (le Roux CW, Aylwin SJ, Batterham RL, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg. 2006;243:108–114). In this article the authors investigated the effect of bariatric surgery on gut hormones secretion. To investigate the hormonal changes after Roux-en-Y gastric bypass (RYGB), basal and meal-stimulated secretion of peptide YY, glucagon-like peptide-1 (GLP-1), polypeptide, insulin, leptin and ghrelin were compared with a group of patients undergoing gastric banding and with 2 control groups composed, respectively, by lean and obese subjects. To further investigate the role of the hormonal response observed in humans, a jejuno-intestinal bypass (JIB) was carried out in Wistar rats. The main goal in the animal experiment was to reproduce hormonal changes observed in humans, postulating that these changes are due to the early arrival of nutrients in the terminal ileum as consequence of the bypass of the jejunum, and to demonstrate the role of PYY in reduction of appetite after bariatric procedures entailing with bypass of part of the small bowel. Comparing JIB rats with sham-operated animals, JIB rats experienced a significant postoperative weight loss with a parallel reduction in food intake. Moreover, the authors excluded the presence of malabsorption in the JIB group using a ballistic bomb calorimeter, therefore referring the modifications in body weight and in food intake solely to the hormonal variations. We discuss some technical aspects of the experimental protocol.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
