A simple and stereospecific synthesis of both (R)- and (S)-GABOB has been developed. The synthetic approach involves the conversion, through organoselenium intermediates, of commercially available ethyl (R)- and (S)-4-chloro-3-hydroxybutyrate into a protected 1,2-amino alcohol with retention of the original configuration.
Short Synthesis of (R)- and (S)-4-Amino-3-Hydroxybutyric Acid (GABOB)
TIECCO, Marcello;TESTAFERRI, Lorenzo;TEMPERINI, Andrea;TERLIZZI, Raffaella Giovanna Pia;BAGNOLI, Luana;MARINI, Francesca;SANTI, Claudio
2005
Abstract
A simple and stereospecific synthesis of both (R)- and (S)-GABOB has been developed. The synthetic approach involves the conversion, through organoselenium intermediates, of commercially available ethyl (R)- and (S)-4-chloro-3-hydroxybutyrate into a protected 1,2-amino alcohol with retention of the original configuration.File in questo prodotto:
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