Enantiomerically pure disubstituted pyrrolidines, recently synthesized from commercially available enantiomerically pure beta-aminoalcohol, were used as starting materials to synthesize enantiomerically pure hexahydro-1H-pyrrolizines and octahydroindolizine through a cyclization reaction promoted by N-(phenylseleno)phtalimide. Similarily, starting from enantiopure 5-(hydroxymethyl)pyrrolidin-2-ones, enantiopure hexahydro-3H-pyrrolizin-3-one were obtained.
Selenium promoted synthesis of enantiopure octahydroindolizines, hexahydro-1H-pyrrolizines, and hexahydro-3H-pyrrolizin-3-ones
TIECCO, Marcello;TESTAFERRI, Lorenzo;BAGNOLI, Luana;
2008
Abstract
Enantiomerically pure disubstituted pyrrolidines, recently synthesized from commercially available enantiomerically pure beta-aminoalcohol, were used as starting materials to synthesize enantiomerically pure hexahydro-1H-pyrrolizines and octahydroindolizine through a cyclization reaction promoted by N-(phenylseleno)phtalimide. Similarily, starting from enantiopure 5-(hydroxymethyl)pyrrolidin-2-ones, enantiopure hexahydro-3H-pyrrolizin-3-one were obtained.File in questo prodotto:
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