Nine new 7-geranyloxycoumarin derivatives differently substituted at position 8 were semi-synthesised. Their topical antiinflammatory activity was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Auraptene (7-geranyloxycoumarin), its 8-methoxy (collinin) and 8-acetoxy derivatives (1micromol/cm2) provoked 50% oedema reduction, similarly to 0.25 micromol/cm2 of the reference drug indomethacin, a nonsteroidal anti-inflammatory drug.
Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins
CURINI, Massimo;MARCOTULLIO, Maria Carla;
2004
Abstract
Nine new 7-geranyloxycoumarin derivatives differently substituted at position 8 were semi-synthesised. Their topical antiinflammatory activity was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Auraptene (7-geranyloxycoumarin), its 8-methoxy (collinin) and 8-acetoxy derivatives (1micromol/cm2) provoked 50% oedema reduction, similarly to 0.25 micromol/cm2 of the reference drug indomethacin, a nonsteroidal anti-inflammatory drug.File in questo prodotto:
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