The synthesis of new tricyclic quinolones, resulting from peri- annelation of 1,2,4-oxadiazine moiety at the N-1/C-8 position of the pharmacophoric quinolone nucleus, are described. None of the synthesized compounds showed interesting antibacterial activity in vitro against the tested strains, with the exception of Klebsiella pneumoniae which was susceptible to all the compounds at MIC values of 8 μg/ml.
New 1,8-peri-Annelated Tricyclic Quinolone Antibacterials
CECCHETTI, Violetta;TABARRINI, Oriana;FRAVOLINI, Arnaldo
2000
Abstract
The synthesis of new tricyclic quinolones, resulting from peri- annelation of 1,2,4-oxadiazine moiety at the N-1/C-8 position of the pharmacophoric quinolone nucleus, are described. None of the synthesized compounds showed interesting antibacterial activity in vitro against the tested strains, with the exception of Klebsiella pneumoniae which was susceptible to all the compounds at MIC values of 8 μg/ml.File in questo prodotto:
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