Cell-mediated and humoral immune responses are functions of distinct subsets of CD4+ cells termed Thl and Th2 cells, respectively (Mosmann and Coffman, 1989). In mucosal colonization and systemic infection of mice with the opportunistic fungal pathogen Candida albicans, a commensal for most healthy humans, Thl cells mediate phagocytedependent protection and are the principal mediators of delayed-type hypersensitivity (DTH). In contrast, Th2 cells induce the production of IgGl and IgE, favour the differentiation of eosinophils and can downregulate some macrophage functions, including the production of candidacidal molecules. Analogous to the response to many environmental allergens (Romagnani, 1994), an apparent bias towards Th2-like reactivity is frequently observed in patients with Candidu-related pathology, such as in symptomatic infection, allergy and asthma. Thl-type responses may thus characterize the carriage of saprophytic yeast and the resistance to disease seen in healthy humans, whereas yeast-specific Th2 responses associate predominantly with pathology. This may have important implications not only for the pathogenesis of Candida infections, but also for concomitant/underlying disease (including coinfection) that may be optimally controlled by either Thl or Th2 cells (Romani et al., 1995a). The therapeutic implications would be manifold (Puccetti et al., 1995), raising important questions such as (1) whether host reactivity to Candida in disease states can be redirected to a Thl pattern of response and (2) whether any interference with the cytokine balance may affect resistance to candidal disease in colonized humans (Romani et al., 1995b).

IL12 in Candida albicans infections.

ROMANI, Luigina;BISTONI, Francesco;MENCACCI, Antonella;CENCI, Elio;SPACCAPELO, Roberta;PUCCETTI, Paolo
1995

Abstract

Cell-mediated and humoral immune responses are functions of distinct subsets of CD4+ cells termed Thl and Th2 cells, respectively (Mosmann and Coffman, 1989). In mucosal colonization and systemic infection of mice with the opportunistic fungal pathogen Candida albicans, a commensal for most healthy humans, Thl cells mediate phagocytedependent protection and are the principal mediators of delayed-type hypersensitivity (DTH). In contrast, Th2 cells induce the production of IgGl and IgE, favour the differentiation of eosinophils and can downregulate some macrophage functions, including the production of candidacidal molecules. Analogous to the response to many environmental allergens (Romagnani, 1994), an apparent bias towards Th2-like reactivity is frequently observed in patients with Candidu-related pathology, such as in symptomatic infection, allergy and asthma. Thl-type responses may thus characterize the carriage of saprophytic yeast and the resistance to disease seen in healthy humans, whereas yeast-specific Th2 responses associate predominantly with pathology. This may have important implications not only for the pathogenesis of Candida infections, but also for concomitant/underlying disease (including coinfection) that may be optimally controlled by either Thl or Th2 cells (Romani et al., 1995a). The therapeutic implications would be manifold (Puccetti et al., 1995), raising important questions such as (1) whether host reactivity to Candida in disease states can be redirected to a Thl pattern of response and (2) whether any interference with the cytokine balance may affect resistance to candidal disease in colonized humans (Romani et al., 1995b).
1995
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/152576
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