A series of dibenzo[1,6]naphthyridindiones, synthesized as modified quinolones, in which the usual carboxylic group was replaced by a heterocyclic amide function, was evaluated for antibacterial activity. None of the target compounds showed any significant antibacterial activity. Semiempirical molecular orbital AM1 calculations allowed us to hypothesize that the lack of activity could depend on amide tautomeric equilibrium.
Dibenzo[1,6]naphthyridindiones as Modified Quinolone Antibacterials
CECCHETTI, Violetta;FRAVOLINI, Arnaldo;SABATINI, STEFANO;TABARRINI, Oriana;
1998
Abstract
A series of dibenzo[1,6]naphthyridindiones, synthesized as modified quinolones, in which the usual carboxylic group was replaced by a heterocyclic amide function, was evaluated for antibacterial activity. None of the target compounds showed any significant antibacterial activity. Semiempirical molecular orbital AM1 calculations allowed us to hypothesize that the lack of activity could depend on amide tautomeric equilibrium.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
