Initially recognized in infection because of antimicrobial activity ('tryptophan starvation'), indoleamine 2,3-dioxygenase (IDO) is widely involved in host immune homeostasis and even immune evasion by microbes that establish commensalism or chronic infection. This review deals with recent findings that could gain IDO a reputation of Jack-of-all-trades in mammalian host/microbe interactions.

Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host.

ZELANTE, TERESA;FALLARINO, Francesca;BISTONI, Francesco;PUCCETTI, Paolo;ROMANI, Luigina
2009

Abstract

Initially recognized in infection because of antimicrobial activity ('tryptophan starvation'), indoleamine 2,3-dioxygenase (IDO) is widely involved in host immune homeostasis and even immune evasion by microbes that establish commensalism or chronic infection. This review deals with recent findings that could gain IDO a reputation of Jack-of-all-trades in mammalian host/microbe interactions.
2009
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/152760
Citazioni
  • ???jsp.display-item.citation.pmc??? 54
  • Scopus 99
  • ???jsp.display-item.citation.isi??? 101
social impact