An 8-month-old female Main Coon with a history of recurrent behavioral changes and anorexia was presented with sternal recumbency and depression. Within 5 days, the cat progressively worsened with symptoms of stupor and coma and was euthanized. At post-mortem examination, a solid, grayish infratentorial mass located in the midline rostrally to the cerebellum, was observed. Histologically, highly cellular clusters of small-to-medium undi􀀀erentiated cells were intermingled with paucicellular areas with fibrillary eosinophilic (neuropil-like) appearance. Numerous multilayered (ependymoblastic) true rosettes were present. Themitotic activity was frequent (up to 15 mitoses/HPF), involving both undi􀀀erentiated cells and rosettes. By immunohistochemistry (IHC), tumor cells were di􀀀usely positive for vimentin, variably for synaptophysin, S-100, and NSE, and focally for NeuN; they were negative for GFAP and CK AE1/AE3. The histological and IHC aspects were consistent with an Embryonal Tumor with Abundant Neuropil and True Rosettes (ETANTR). Embryonal neoplasms of the central nervous system(CNS) are characterized by primitive undi􀀀erentiated cells, able to develop toward neuronal, glial, ependymal, and mesenchymal lines. Although extremely rare, juvenile embryonal tumors should be considered in the di􀀀erentials of CNS disorders in young cats.

Case report: Infratentorial Embryonal Tumor with abundant neuropil and True Rosettes (ETANTR) in a 8-month-old Maine Coon

Greta Foiani
;
Maria Teresa Mandara
Formal Analysis
;
2022

Abstract

An 8-month-old female Main Coon with a history of recurrent behavioral changes and anorexia was presented with sternal recumbency and depression. Within 5 days, the cat progressively worsened with symptoms of stupor and coma and was euthanized. At post-mortem examination, a solid, grayish infratentorial mass located in the midline rostrally to the cerebellum, was observed. Histologically, highly cellular clusters of small-to-medium undi􀀀erentiated cells were intermingled with paucicellular areas with fibrillary eosinophilic (neuropil-like) appearance. Numerous multilayered (ependymoblastic) true rosettes were present. Themitotic activity was frequent (up to 15 mitoses/HPF), involving both undi􀀀erentiated cells and rosettes. By immunohistochemistry (IHC), tumor cells were di􀀀usely positive for vimentin, variably for synaptophysin, S-100, and NSE, and focally for NeuN; they were negative for GFAP and CK AE1/AE3. The histological and IHC aspects were consistent with an Embryonal Tumor with Abundant Neuropil and True Rosettes (ETANTR). Embryonal neoplasms of the central nervous system(CNS) are characterized by primitive undi􀀀erentiated cells, able to develop toward neuronal, glial, ependymal, and mesenchymal lines. Although extremely rare, juvenile embryonal tumors should be considered in the di􀀀erentials of CNS disorders in young cats.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1534355
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