This study illustrates the sensing and wound healing properties of silk fibroin in combination with peptide patterns, with an emphasis on the printability of multilayered grids, and envisions possible applications of these next-generation silk-based materials. Functionalized silk fibers covalently linked to an arginine–glycine–aspartic acid (RGD) peptide create a platform for preparing a biomaterial ink for 3D printing of grid-like piezoresistors with wound-healing and sensing properties. The culture medium obtained from 3D-printed silk fibroin enriched with RGD peptide improves cell adhesion, accelerating skin repair. Specifically, RGD peptide-modified silk fibroin demonstrated biocompatibility, enhanced cell adhesion, and higher wound closure rates at lower concentration than the neat peptide.

Biomaterial Inks from Peptide-Functionalized Silk Fibers for 3D Printing of FuturisticWound-Healing and Sensing Materials

M. R. Ceccarini
Investigation
;
V. Palazzi
Investigation
;
R. Salvati
Investigation
;
S. Bonafoni
Investigation
;
P. Mezzanotte
Investigation
;
M. Codini
Investigation
;
T. Beccari
Writing – Review & Editing
;
L. Roselli
Writing – Review & Editing
;
L. Valentini
Conceptualization
2023-01-01

Abstract

This study illustrates the sensing and wound healing properties of silk fibroin in combination with peptide patterns, with an emphasis on the printability of multilayered grids, and envisions possible applications of these next-generation silk-based materials. Functionalized silk fibers covalently linked to an arginine–glycine–aspartic acid (RGD) peptide create a platform for preparing a biomaterial ink for 3D printing of grid-like piezoresistors with wound-healing and sensing properties. The culture medium obtained from 3D-printed silk fibroin enriched with RGD peptide improves cell adhesion, accelerating skin repair. Specifically, RGD peptide-modified silk fibroin demonstrated biocompatibility, enhanced cell adhesion, and higher wound closure rates at lower concentration than the neat peptide.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1538018
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