The presence and activity of vitamin E in the organism as well as its role in disease prevention depend, as for any other micro-constituent in food, on a number of factors related to its release from the food matrix, extent of absorption, and metabolic fate. Biotransformation can be defined as the sum of processes in which vitamin E compounds are altered by the body. It involves the bioactivation and production of reactive metabolites, a series of processes generally referred to as ‘‘vitamin E metabolism.’’ This chapter will provide an overview of the known and less known steps of vitamin E biotransformation in humans. Due to recent advances related to the biological activities and metabolic proces-sing of vitamin E compounds, particular attention will be given to the description of the formation, identification, and functions of vitamin E metabolites. The hypothesis of a transformation‐dependent bioactivation of vitamin E represents an intriguing and emerging aspect of research that deserves further investigation.
Vitamin E biotransformation in humans.
Galli F.;Polidori M. C.;Mecocci P.;
2007
Abstract
The presence and activity of vitamin E in the organism as well as its role in disease prevention depend, as for any other micro-constituent in food, on a number of factors related to its release from the food matrix, extent of absorption, and metabolic fate. Biotransformation can be defined as the sum of processes in which vitamin E compounds are altered by the body. It involves the bioactivation and production of reactive metabolites, a series of processes generally referred to as ‘‘vitamin E metabolism.’’ This chapter will provide an overview of the known and less known steps of vitamin E biotransformation in humans. Due to recent advances related to the biological activities and metabolic proces-sing of vitamin E compounds, particular attention will be given to the description of the formation, identification, and functions of vitamin E metabolites. The hypothesis of a transformation‐dependent bioactivation of vitamin E represents an intriguing and emerging aspect of research that deserves further investigation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
