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Rare missense variant (R251G) on APOE counterbalances the Alzheimer’s disease risk associated with APOE‐ε4

Guen, Yann Le;Belloy, Michael E;Grenier‐Boley, Benjamin;de Rojas, Itziar;Castillo, Atahualpa;Jansen, Iris E;Nicolas, Aude;Bellenguez, Céline;Dalmasso, Carolina;Küçükali, Fahri;Eger, Sarah J;Álvarez‐Martínez, Victoria;Arosio, Beatrice;Benussi, Luisa;Boland, Anne;Borroni, Barbara;Bullido, María J.;Caffarra, Paolo;Clarimón, Jordi;Daian, Delphine;Daniele, Antonio;Debette, Stéphanie;Deleuze, Jean‐François;Dichgans, Martin;Dufouil, Carole;Duzel, Emrah;Galimberti, Daniela;García‐Alberca, Jose María;García‐González, Pablo;Giedraitis, Vilmantas;Grimmer, Timo;Graff, Caroline;Grunblatt, Edna;Hanon, Olivier;Hausner, Lucrezia;Heilmann‐Heimbach, Stefanie;Holstege, Henne;Hort, Jakub;Jurgen, Deckert;Kuulasmaa, Teemu;van der Lugt, Aad;Masullo, Carlo;Mecocci, Patrizia

;Mehrabian, Shima;de Mendonça, Alexandre;Boada, Mercè;Mir, Pablo;Moebus, Susanne;Moreno, Fermin;Nacmias, Benedetta;Nicolas, Gaël;Papenberg, Goran;Parnetti, Lucilla

;Pasquier, Florence;Pastor, Pau;Peters, Oliver;Pijnenburg, Yolande A. L.;Piñol‐Ripoll, Gerard;Popp, Julius;Molina, Laura;Puerta, Raquel;Pérez‐Tur, Jordi;Rainero, Innocenzo;Ramakers, Inez H. G. B.;Rasmussen, Katrine Laura;Real, Luis Miguel;Riedel‐Heller, Steffi G.;Rodríguez, Eloy Rodríguez;Royo, José Luís;Rujescu, Dan;Scarmeas, Nikolaos;Scheltens, Philip;Scherbaum, Norbert;Schneider, Anja;Seripa, Davide;Soininen, Hilkka;Solfrizzi, Vincenzo;Spalletta, Gianfranco;Squassina, Alessio;van Swieten, John C;Sanchez‐Valle, Raquel;Tegos, Thomas;Thomassen, Jesper Qvist;Tremolizzo, Lucio;Verhey, Frans R. J.;Vyhnalek, Martin;Wiltfang, Jens;He, Zihuai;Napolioni, Valerio;Amouyel, Philippe;Jessen, Frank;Kehoe, Patrick G;van Duijn, Cornelia M;Tsolaki, Magda;Sanchez‐Juan, Pascual;Sleegers, Kristel;Ingelsson, Martin;Rossi, Giacomina;Hiltunen, Mikko;Sims, Rebecca;van der Flier, Wiesje M.;Ramirez, Alfredo;Andreassen, Ole;Frikke‐Schmidt, Ruth;Williams, Julie;Ruiz, Agustin;Lambert, Jean‐Charles;Greicius, Michael D

2022