Insulin may affect breast cancer (BC) risk and prognosis. Exercise reduces insulin in obese BC survivors. We designed a randomised controlled trial to test the effect of an aerobic exercise intervention (AEI) on insulin parameters and body composition in non-obese BC women without insulin resistance. Thirty-eight BC women were randomised into an intervention group (IG=18) or control group (CG=20). IG participated in a structured AEI for 3months, while CG received only the Word Cancer Research Fund/American Institute Cancer Research (WCRF/AICR) recommendation to be physically active. Fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) index, metabolic parameters and body composition were collected at baseline and after the AEI. IG reduced insulin and HOMA-IR index by 15% and 14%, while CG increased these parameters (+12% and +16%). Insulin changed differently over time in the two randomised groups (p(interaction)=.04). The between-group differences in the change of insulin (IG=-1.2U/ml versus CG=+0.8U/ml) and HOMA-IR index (IG=-0.26 versus CG=+0.25) were respectively significant (p=.04) and non-significant (p=.06). IG significantly improved lower limb muscle mass in comparison with CG (p=.03). A structured AEI may improve insulin, HOMA-IR index and body composition in non-obese BC survivors without insulin resistance.
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