Whether microglia that reside in different central nervous system niches have distinct functions is unclear. O'Koren and Yu et al. now reveal key functional differences in microglia across two anatomically distinct locations in the retina during homeostasis. Furthermore, in degenerative conditions, microglia migrate to another location where they undergo transcriptional reprogramming and contribute to retinal cytoprotection.

Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration

Wong A. Y. W.;
2019

Abstract

Whether microglia that reside in different central nervous system niches have distinct functions is unclear. O'Koren and Yu et al. now reveal key functional differences in microglia across two anatomically distinct locations in the retina during homeostasis. Furthermore, in degenerative conditions, microglia migrate to another location where they undergo transcriptional reprogramming and contribute to retinal cytoprotection.
2019
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11391/1549338
Citazioni
  • ???jsp.display-item.citation.pmc??? 116
  • Scopus 211
  • ???jsp.display-item.citation.isi??? 200
social impact