The worldwide search for new active compounds useful together with, or in substitution of currently used antimicrobial molecules has oriented the attention of academy and industry towards the development of novel drugs. This is particularly important in consideration of the increasing number of microbial genotypes that are resistant to many of the currently employed antimicrobial drugs. Hydrolysable tannins (HTs), secondary metabolites widely distributed in the plant kingdom, are generally multiple esters of gallic acid with glucose. HTs have been shown to be effective antagonists against viruses, bacteria and eukaryotic microorganisms. The present review examines the antimicrobial and antiviral activity of HTs, the mechanism(s) of action, and some structure-activity relationships.
Antimicrobial and antiviral activity of hydrolysable tannins.
BUZZINI, Pietro;GORETTI, MARTA;BRANDA, EVA;TURCHETTI, BENEDETTA;
2008
Abstract
The worldwide search for new active compounds useful together with, or in substitution of currently used antimicrobial molecules has oriented the attention of academy and industry towards the development of novel drugs. This is particularly important in consideration of the increasing number of microbial genotypes that are resistant to many of the currently employed antimicrobial drugs. Hydrolysable tannins (HTs), secondary metabolites widely distributed in the plant kingdom, are generally multiple esters of gallic acid with glucose. HTs have been shown to be effective antagonists against viruses, bacteria and eukaryotic microorganisms. The present review examines the antimicrobial and antiviral activity of HTs, the mechanism(s) of action, and some structure-activity relationships.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
