Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent 19F-labelled, 10B-enriched pboronophenylalanine-fructose (19F-BPA-fr) complexwas obtained. 1H, 19F, 13C and 10B magnetic resonance spectroscopy (MRS) of the 19F-BPA-fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using 19F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on 19F-BPA through 19F NMR will be feasible.
Multi-nuclear MRS and 19F MRI of 19F-labelled and 10B-enriched p-boronophenylalanine-fructose complex to optimize boron neutron capture therapy: phantom studies at high magnetic fields
CAMPANELLA, Renzo;
2006
Abstract
Reaction yield optimization for the synthesis and the complexation of a boron neutron capture therapy agent 19F-labelled, 10B-enriched pboronophenylalanine-fructose (19F-BPA-fr) complexwas obtained. 1H, 19F, 13C and 10B magnetic resonance spectroscopy (MRS) of the 19F-BPA-fr complex in aqueous and rat blood solution phantoms and its spatial distribution mapping using 19F magnetic resonance imaging (MRI) results are reported. 7 T and 9.4 T magnetic fields were used to perform MRI and MRS respectively. Our in vitro results suggest that in vivo studies on 19F-BPA through 19F NMR will be feasible.File in questo prodotto:
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