INTRODUCTION:The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk.METHODS:A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity).RESULTS:Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion.DISCUSSION:Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.
Early Antibody Dynamics in a Prospective Cohort of Children At Risk of Celiac Disease
Valitutti, Francesco;Morelli, Annalisa;
2023
Abstract
INTRODUCTION:The purpose of this study was to identify possible serum biomarkers predicting celiac disease (CD) onset in children at risk.METHODS:A subgroup from an ongoing, international prospective study of children at risk of CD was classified according to an early trajectory of deamidated gliadin peptides (DGPs) immunoglobulin (Ig) G and clinical outcomes (CD, potential CD, and CD autoimmunity).RESULTS:Thirty-eight of 325 children developed anti-tissue transglutaminase IgA antibody (anti-tTG IgA) seroconversion. Twenty-eight of 38 children (73.6%) showed an increase in anti-DGPs IgG before their first anti-tTG IgA seroconversion.DISCUSSION:Anti-DGPs IgG can represent an early preclinical biomarker predicting CD onset in children at risk.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
