Based on low solubility in water and high membrane permeability, resveratrol is collocated in the second class of the Biopharmaceutical Classification System, with limited absorption derived from a low dissolution rate. Solid microdispersion of resveratrol supported by magnesium dihydroxide (Resv@MDH, trademark Revifast (R)) represents a physical mixture of resveratrol (30% w/w) and magnesium dihydroxide (70% w/w) obtained by traditional techniques, such as mixing and micronization under appropriate conditions. Establishing the wide use of Revifast (R) in food supplements, in the present work we deepen its physicochemical characterization by using diffractometric and infrared analysis. No novel species are found in the Resv@MDH mixture except magnesium dihydroxide and resveratrol extracted from Polygonum cuspidatum. The results herein reported strengthened the safety of Revifast (R) ingredients for resveratrol-based food supplements.
New insights on resveratrol supported by magnesium dihydroxide (Revifast®)
Roberto Spogli;Andrea Biagini;Federica Presciutti;Francesco Ragonese;Rossana Giulietta Iannitti;Giada Ceccarelli;Gabriele Brecchia;Laura Menchetti;Michela Codini;Maria Rachele Ceccarini;Paola Sabbatini;Bernard Fioretti
2024
Abstract
Based on low solubility in water and high membrane permeability, resveratrol is collocated in the second class of the Biopharmaceutical Classification System, with limited absorption derived from a low dissolution rate. Solid microdispersion of resveratrol supported by magnesium dihydroxide (Resv@MDH, trademark Revifast (R)) represents a physical mixture of resveratrol (30% w/w) and magnesium dihydroxide (70% w/w) obtained by traditional techniques, such as mixing and micronization under appropriate conditions. Establishing the wide use of Revifast (R) in food supplements, in the present work we deepen its physicochemical characterization by using diffractometric and infrared analysis. No novel species are found in the Resv@MDH mixture except magnesium dihydroxide and resveratrol extracted from Polygonum cuspidatum. The results herein reported strengthened the safety of Revifast (R) ingredients for resveratrol-based food supplements.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.