Parkinson disease (PD), like other neurodegenerative diseases, is characterized by a long preclinical phase, followed by a prodromal stage. After these phases, neurodegeneration spreads in the CNS, leading to network dysfunction, irreversible neuronal loss, and the disabling clinical picture.(1) Clinical diagnosis of PD is achieved only when motor symptoms become evident,(2) indicating that diagnosis and potential therapeutic interventions occur at a late stage.
Biomarker-Based Prediction of Parkinson Disease: Time for a Shift in Neurologists' Attitude Toward Neurodegenerative Diseases
Parnetti, Lucilla;Gaetani, Lorenzo
2024
Abstract
Parkinson disease (PD), like other neurodegenerative diseases, is characterized by a long preclinical phase, followed by a prodromal stage. After these phases, neurodegeneration spreads in the CNS, leading to network dysfunction, irreversible neuronal loss, and the disabling clinical picture.(1) Clinical diagnosis of PD is achieved only when motor symptoms become evident,(2) indicating that diagnosis and potential therapeutic interventions occur at a late stage.File in questo prodotto:
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