• Synthetic cannabinoid receptor agonists were enantioseparated with Whelk-O®1 CSPs. • Efficient enantioseparations were obtained under reversed-phase conditions. • The developed HPLC method was compatible to MS detection. • The ICCA concept was useful to appraise the enantiopurity of the studied compounds. • Coupling ECD analysis to in silico simulations allowed to establish the EEO.
Chromatographic enantioresolution and stereochemical characterization of synthetic cannabinoid receptor agonists with Whelk-O®1 chiral stationary phases under mass spectrometry compatible reversed-phase conditions: A study case with seized samples
Varfaj, Ina;Di Michele, Alessandro;Carotti, Andrea
;Sardella, Roccaldo
;
2024
Abstract
• Synthetic cannabinoid receptor agonists were enantioseparated with Whelk-O®1 CSPs. • Efficient enantioseparations were obtained under reversed-phase conditions. • The developed HPLC method was compatible to MS detection. • The ICCA concept was useful to appraise the enantiopurity of the studied compounds. • Coupling ECD analysis to in silico simulations allowed to establish the EEO.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Carotti1.pdf
accesso aperto
Tipologia di allegato:
PDF-editoriale
Licenza:
Creative commons
Dimensione
3.4 MB
Formato
Adobe PDF
|
3.4 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
