Striated duct adenoma of the salivary gland is an uncommon benign tumor identified by its single-layered duct epithelium and striated appearance of tumor cell membranes. To date, only eight cases have been documented in medical literature. Here, we describe an additional case, initially assessed both radiologically and histologically as a vascular lesion. In a 79-year-old male with no prior symptoms, a painless tumor was found in the left hemipalate. Initial concerns leaned towards arteriovenous malformation following an incisional biopsy. Subsequently, the patient underwent embolization and then had the lesion removed. Following an extensive histopathological assessment, the tumor was definitively identified as striated duct adenoma. The patient is currently undergoing follow-up care. Encased within a distinct capsule, these tumors can arise in both major and minor salivary glands. Originating from striated ducts, they lack myoepithelial differentiation, leading to occasional or absent expression of myoepithelial markers at immunohistochemical analysis. The adenoma originating from the striated ducts is clearly delineated, composed of interconnected tubules with minimal stroma. It may exhibit a dense vascular network. This particular tumor type ranks among the rarest benign tumors affecting the salivary glands, with only a handful of cases documented in the medical literature. The aim of this study is to discuss an unusual and challenging presentation of this condition, illustrated through a clinical case originating from the minor salivary glands of the palate, highlighting the diagnostic and treatment approach. Data Availability: The data that support the findings of this study are available on request from the corresponding author, (G.M.).
Salivary gland striated duct adenoma of palate: A rare case report
Mandarano M.;Sidoni A.;Tullio A.
2025
Abstract
Striated duct adenoma of the salivary gland is an uncommon benign tumor identified by its single-layered duct epithelium and striated appearance of tumor cell membranes. To date, only eight cases have been documented in medical literature. Here, we describe an additional case, initially assessed both radiologically and histologically as a vascular lesion. In a 79-year-old male with no prior symptoms, a painless tumor was found in the left hemipalate. Initial concerns leaned towards arteriovenous malformation following an incisional biopsy. Subsequently, the patient underwent embolization and then had the lesion removed. Following an extensive histopathological assessment, the tumor was definitively identified as striated duct adenoma. The patient is currently undergoing follow-up care. Encased within a distinct capsule, these tumors can arise in both major and minor salivary glands. Originating from striated ducts, they lack myoepithelial differentiation, leading to occasional or absent expression of myoepithelial markers at immunohistochemical analysis. The adenoma originating from the striated ducts is clearly delineated, composed of interconnected tubules with minimal stroma. It may exhibit a dense vascular network. This particular tumor type ranks among the rarest benign tumors affecting the salivary glands, with only a handful of cases documented in the medical literature. The aim of this study is to discuss an unusual and challenging presentation of this condition, illustrated through a clinical case originating from the minor salivary glands of the palate, highlighting the diagnostic and treatment approach. Data Availability: The data that support the findings of this study are available on request from the corresponding author, (G.M.).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.